Hemoglobin, autoxidation, free radical generation, tissue injury and oxidative stress: An interesting correlation associated to the vascular accidents

Abstract

The present manuscript is focused on the relation between hemoglobin, autoxidation, free radical generation (with especial emphasis on reactive oxygen species (ROS) and reactive nitrogen species (RNS)), and the biochemical and physiological processes that occur in some biological and pathological situations, mainly vascular accidents, such as stroke and myocardial infarction. Indeed, several types of free radicals are quite associated with the chemical processes of circulatory accidents as well as the subsequent biological tissue lesions. Interestingly, the hemorrhagic and ischemic circulatory processes of vascular diseases are related to the presence of several free radical species. This work presents various correlations between these chemical and biochemical agents, favoring to understand the important role of the free radicals in this kind of disease. It is also suggested that the analysis of these chemical species could constitute a strategy to evaluate the evolution of the circulatory disease.