Canine cognitive dysfunction syndrome: Alzheimer’s in dogs

Authors

DOI:

https://doi.org/10.31533/pubvet.v17n9e1442

Keywords:

Canine Alzheimer's, Alzheimer's disease, neurodegenerative, senility

Abstract

Considering the advances in veterinary medicine, improvements in nutrition and greater care by owners, the life expectancy of dogs is increasing significantly. However, this increase in longevity is accompanied by the more frequent appearance of diseases related to aging, one of which is the Canine Cognitive Dysfunction Syndrome (CCDS). This syndrome affects senior dogs not only physically, but cognitively as well. It is a neurodegenerative disease that develops gradually and, initially, may go unnoticed, often being confused with the natural aging processes. Its diagnosis is challenging and complex, depending on several factors, mainly involving the exclusion of other common clinical suspicions in elderly animals, in addition to a thorough anamnesis conducted by the veterinarian, while also taking into account information provided by the tutors. Questionnaires that address behavioral and cognitive aspects of the animal can be very useful to direct the diagnosis. Once the diagnosis is confirmed, it is important to immediately initiate treatment measures aimed at the comfort and well-being of the animal. Environmental enrichment strategies play an essential role, involving the introduction of objects that stimulate the dog's cognition. In addition, dietary adjustments are recommended, including adding vitamins C and E, as well as omega-3 and omega-6 fatty acids to the diet. Some medications, such as Revimax, can also be given as part of the treatment. The objective of the treatment is to prolong and promote quality of life for the animal, seeking to delay the progression of the syndrome, although it does not have a definitive cure so far. It is interesting to note that this syndrome has similarities with Alzheimer's disease in humans (ADH). Therefore, studies and research on this disease can contribute to the development of more effective approaches aimed at treating CCDS.

References

Azkona, G., García‐Belenguer, S., Chacón, G., Rosado, B., León, M., & Palacio, J. (2009). Prevalence and risk factors of behavioural changes associated with age‐related cognitive impairment in geriatric dogs. Journal of Small Animal Practice, 50(2), 87–91. https://doi.org/10.1111/j.1748-5827.2008.00718.x.

Barbosa, K. B. F., Costa, N. M. B., Alfenas, R. de C. G., De Paula, S. O., Minim, V. P. R., & Bressan, J. (2010). Estresse oxidativo: conceito, implicações e fatores modulatórios. Revista de Nutrição, 23(4), 629–643.

Bruns, A. I. (2009). Alzheimer’s disease. British Medical Journal, 338, 464–471.

Davies, M. (2012). Geriatric clinics in practice. Veterinary Focus, 22(2), 15–22.

Dewey, C. W., & Costa, R. C. (2016). Practical guide to canine and feline neurology (3 Ed.). Wiley Blackwell.

Dewey, C. W., Davies, E. S., Xie, H., & Wakshlag, J. J. (2019). Canine cognitive dysfunction: pathophysiology, diagnosis, and treatment. Veterinary Clinics: Small Animal Practice, 49(3), 477–499. https://doi.org/10.1016/j.cvsm.2019.01.013.

Gottlieb, M. G. V., Cruz, I. B. M., Schwanke, C. H. A., & Bodanese, L. C. (2010). Estresse oxidativo como fator de risco cardiometabólico emergente. Scientia Medica, 20(3), 243–249.

Gunn-Moore, D. A. (2011). Cognitive dysfunction in cats: clinical assessment and management. Topics in Companion Animal Medicine, 26(1), 17–24.

Head, E. (2013). A canine model of human aging and Alzheimer’s disease. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1832(9), 1384–1389. https://doi.org/10.1016/j.bbadis.2013.03.016.

Heckler, M. C. T., Svicero, D. J., & Amorim, R. M. (2011). Síndrome da disfunção cognitiva em cães. Clínica Veterinária, 90, 70–74.

Kurinami, H., Sato, N., Shinohara, M., Takeuchi, D., Takeda, S., Shimamura, M., Ogihara, T., & Morishita, R. (2008). Prevention of amyloid β-induced memory impairment by fluvastatin, associated with the decrease in amyloid β accumulation and oxidative stressin amyloid β injection mouse model. International Journal of Molecular Medicine, 21(5), 531–537. https://doi.org/10.3892/ijmm.21.5.531.

LaFerla, F. M., Green, K. N., & Oddo, S. (2007). Intracellular amyloid-β in Alzheimer’s disease. Nature Reviews Neuroscience, 8(7), 499–509.

Landsberg, G. M., DePorter, T., & Araujo, J. A. (2011). Clinical signs and management of anxiety, sleeplessness, and cognitive dysfunction in the senior pet. Veterinary Clinics: Small Animal Practice, 41(3), 565–590. https://doi.org/10.1016/j.cvsm.2011.03.017.

Landsberg, G. M., & Head, E. (2008). Senilidade e seus efeitos sobre o comportamento. In J. D. Hoskins (Ed.), Geriatria e Gerontologia do Cão e Gato (pp. 33–48). Roca, Brasil.

Landsberg, G. M., Nichol, J., & Araujo, J. A. (2012). Cognitive dysfunction syndrome: a disease of canine and feline brain aging. Veterinary Clinics: Small Animal Practice, 42(4), 749–768. https://doi.org/10.1016/j.cvsm.2012.04.003.

Madari, A., Farbakova, J., Katina, S., Smolek, T., Novak, P., Weissova, T., Novak, M., & Zilka, N. (2015). Assessment of severity and progression of canine cognitive dysfunction syndrome using the Canine Dementia Scale (CADES). Applied Animal Behaviour Science, 171, 138–145. https://doi.org/10.1016/j.applanim.2015.08.034.

Moussa‐Pacha, N. M., Abdin, S. M., Omar, H. A., Alniss, H., & Al‐Tel, T. H. (2020). BACE1 inhibitors: Current status and future directions in treating Alzheimer’s disease. Medicinal Research Reviews, 40(1), 339–384. https://doi.org/10.1002/med.21622.

Nešić, S., Kukolj, V., Marinković, D., Vučićević, I., & Jovanović, M. (2017). Histological and immunohistochemical characteristics of cerebral amyloid angiopathy in elderly dogs. Veterinary Quarterly, 37(1), 1–7. https://doi.org/10.1080/01652176.2016.1235301.

Osella, M. C., Re, G., Odore, R., Girardi, C., Badino, P., Barbero, R., & Bergamasco, L. (2007). Canine cognitive dysfunction syndrome: prevalence, clinical signs and treatment with a neuroprotective nutraceutical. Applied Animal Behaviour Science, 105(4), 297–310. https://doi.org/10.1016/j.applanim.2006.11.007.

Pantoja, L. N. (2010). Contribuição ao diagnóstico clínico da disfunção cognitiva canina. Universidade Federal Rural do Rio de Janeiro.

Pineda, S., Olivares, A., Mas, B., & Ibañez, M. (2014). Cognitive dysfunction syndrome: updated behavioral and clinical evaluations as a tool to evaluate the well-being of aging dogs. Archivos de Medicina Veterinaria, 46(1), 1–12. https://doi.org/10.4067/S0301-732X2014000100002.

Salvin, H. E., McGreevy, P. D., Sachdev, P. S., & Valenzuela, M. J. (2010). Under diagnosis of canine cognitive dysfunction: a cross-sectional survey of older companion dogs. The Veterinary Journal, 184(3), 277–281. https://doi.org/10.1016/j.tvjl.2009.11.007.

Sousa, A. V, & Souza, L. F. C. B. (2019). Síndrome da disfunção cognitiva em cães–revisão de literatura. Ciência Veterinária UniFil, Londrina, 1(3), 121–137.

Travancinha, J. D. N. P., & Pomba, M. C. M. F. (2015). Alterações comportamentais sugestivas de síndrome da disfunção cognitiva em cães geriátricos. Universidade de Lisboa (Portugal).

Yamada, K., Tanaka, T., Senzaki, K., Kameyama, T., & Nabeshima, T. (1998). Propentofylline improves learning and memory deficits in rats induced by β-amyloid protein-(1-40). European Journal of Pharmacology, 349(1), 15–22. https://doi.org/10.1016/s0014-2999(98)00166-6.

Published

2023-09-18

Issue

Section

Medicina veterinária

How to Cite

Canine cognitive dysfunction syndrome: Alzheimer’s in dogs. (2023). Pubvet, 17(09), e1442. https://doi.org/10.31533/pubvet.v17n9e1442

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