Midazolam or fentanyl for co-induction of propofol anesthesia in bitches premedicated with acepromazine-morphine
DOI:
https://doi.org/10.31533/pubvet.v16n09a1216.1-7Keywords:
Anesthesia, benzodiazepine, phenothiazine, opioid, sedationAbstract
The aim of the present study was to evaluate the ability of midazolam and fentanyl to reduce the induction dose of propofol and the quality of induction of bitches premedicated with acepromazine (0,03 mg/kg) and morphine (0,3 mg/kg). Thirty minutes after premedication administration (T30), heart rate (HR), respiratory rate (RR), systolic arterial pressure (SAP), rectal temperature (RT) was evaluated. Then, the dogs were randomly assigned to receive one of three treatments (n = 8): midazolam-propofol (MP group), fentanyl-propofol (FP group) or saline-propofol (SP group). Immediately after administration of the co-inducing agent, anesthesia was induced with IV propofol (2 mg/kg/minute). The dose of propofol required for orotracheal intubation, the quality of induction and the occurrence of side effects were recorded. At T30, a sedative increase was observed in MP, FP and SP groups compared to baseline (P < 0.05). At T30, a decrease in HR, SAP and TR was observed in relation to baseline (P < 0.05). There was no difference between groups regarding sedation scores, HR, RR, SBP, TR, propofol induction dose and quality of anesthetic induction (P > 0.05). Apnea was observed in four dogs in the MP group and in two dogs in the FP group. One dog in the MP group presented muscle stiffness. At the doses used, midazolam and fentanyl were not able to reduce the propofol induction dose in dogs premedicated with acepromazine-morphine. The quality of anesthetic induction was excellent, with possible occurrence of apnea and muscle stiffness. The acepromazine-morphine combination results in mild to moderate sedation, and a decrease in HR, SAP and RT.
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