Immunodetection of Leishmania infantum chagasi in internal lymph nodes of dogs naturally infected
DOI:
https://doi.org/10.22256/pubvet.v8n16.1761Keywords:
dogs, lymphadenopathy, visceral leishmaniasis, immunohistochemistry.Abstract
The lymphadenopathy is a major change in Canine Visceral Leishmaniasis (CVL), but there are few studies comparing and focusing on the internal lymph nodes. The objective of this study was to assess the parasite load in the mesenteric and iliac lymph nodes from 17 dogs naturally infected with Leishmania infantum chagasi, coming from Araçatuba (SP), an endemic area for visceral leishmaniasis (VL). Of these animals, 10 were symptomatic (CS group) and seven were asymptomatic (SS group). Immunodetection of the parasite was taken by immunohistochemical technique with hyperimmune sera from seropositive dog for LVC. The parasite load was higher in dogs with clinical signs of CVL in both lymph nodes. The iliac lymph node had the highest average of parasitized macrophages, although no differences between CS and SS groups. With this it can be concluded that the symptomatic dogs had the highest parasite load, suggesting visceralization of the parasite Leishmania infantum chagasi which seems to be related to the evolution of clinical signs in infected dogs.
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Copyright (c) 2014 Márcio de Barros Bandarra, Pamela Rodrigues Reina Moreira,Rosemeri de Oliveira Vasconcelos
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