Abordagens alternativas para tratamento da otite externa canina causada por Malassezia pachydermatis

Revisão e recomendações

Autores

  • Roger Ferreira Gomes Federal University of Rio Grande do Sul https://orcid.org/0000-0003-4432-2231
  • Manoela Almeida Martins Mace Federal University of Rio Grande do Sul
  • Érico Silva de Loreto Sobresp Faculty of Health Sciences
  • Alexandre Meneghello Fuentefria Federal University of Rio Grande do Sul
  • Regis Adriel Zanette Universidade Federal do Rio Grande do Sul https://orcid.org/0000-0003-4432-2231

DOI:

https://doi.org/10.31533/pubvet.v18n02e1544

Palavras-chave:

Tratamentos alternativos, resistência antimicrobiana, Malassezia pachydermatis, otite externa

Resumo

Malassezia pachydermatis é um patógeno fúngico que frequentemente causa dermatites caninas e infecções de ouvido. O tratamento atual para otite externa, que envolve medicamentos antifúngicos, antibióticos e glicocorticoides, enfrenta desafios devido à resistência aos medicamentos e à adesão dos donos de animais de estimação ao tratamento prolongado. Esta revisão investiga métodos de tratamento alternativos além dos medicamentos antifúngicos convencionais e fornece recomendações para seu uso prático. Esses métodos incluem fitoterapias, substâncias químicas, reposicionamento de medicamentos, limpadores de ouvido, métodos alternativos de administração e dietas terapêuticas. Mais pesquisas, ensaios clínicos e estudos comparativos são necessários para validar a eficácia destes tratamentos alternativos e incorporá-los na prática clínica. Ao implementar estes métodos, os protocolos de tratamento tradicionais podem ser otimizados, a resistência aos medicamentos pode ser minimizada e o tratamento da otite externa por M. pachydermatis em cães pode ser melhorado, seguindo a abordagem One Health que promove o uso prudente de antimicrobianos.

Referências

Angus, J. C. (2004). Otic cytology in health and disease. The Veterinary Clinics of North America. Small Animal Practice, 34, 411–424. https://doi.org/10.1016/j.cvsm.2003.10.005.

Bensignor, E., & Grandemange, E. (2006). Comparison of an antifungal agent with a mixture of antifungal, antibiotic and corticosteroid agents for the treatment of Malassezia species otitis in dogs. The Veterinary Record, 158, 193–195. https://doi.org/10.1136/vr.158.6.193.

Bismarck, D., Dusold, A., Heusinger, A., & Müller, E. (2020). Antifungal in vitro activity of essential oils against clinical isolates of Malassezia pachydermatis from canine ears: a report from a practice laboratory. Complementary Medicine Research, 27(3), 143–154. https://doi.org/10.1159/000504316.

Blake, J. D., Keil, D. D. P., Kwochka, K. D., Palma, K. P., & Schofield, J. D. (2017). Evaluation of a single-administration ototopical treatment for canine otitis externa: a randomised trial. Veterinary Record Open, 4, e000219. https://doi.org/10.1136/vetreco-2017-000219.

Bonin, E., Carvalho, V. M., Avila, V. D., Santos, N. C. A., Zanqueta, É. B., Lanchero, C. A. C., Previdelli, I. T. S., Nakamura, T. U., Abreu Filho, B. Al, & Prado, I. N. (2020). Baccharis dracunculifolia: Chemical constituents, cytotoxicity and antimicrobial activity. LWT - Food Science and Technology, 120(108920), 1–10. https://doi.org/10.1016/j.lwt.2019.108920.

Cafarchia, C., Immediato, D., Di Paola, G., Magliani, W., Ciociola, T., Conti, S., Otranto, D., & Polonelli, L. (2014). In vitro and in vivo activity of a killer peptide against Malassezia pachydermatis causing otitis in dogs. Medical Mycology, 52, 350–355. https://doi.org/10.1093/mmy/myt016.

Campbell, J. J., Coyner, K. S., Rankin, S. C., Lewis, T. P., Schick, A. E., & Shumaker, A. K. (2010). Evaluation of fungal flora in normal and diseased canine ears. Veterinary Dermatology, 21, 619–625. https://doi.org/10.1111/j.1365-3164.2010.00927.x.

Chan, W. Y., Hickey, E. E., M, Khazandi., Page, S. W., Trott, D. J., & Hill, P. B. (2018a). In vitro antimicrobial activity of monensin against common clinical isolates associated with canine otitis externa. Comparative Immunology, Microbiology, and Infectious Diseases, 57, 34–38. https://doi.org/10.1016/j.cimid.2018.05.001.

Chan, W. Y., Hickey, E. E., Khazandi, M., Page, S. W., Trott, D. J., & Hill, P. B. (2018b). In vitro antimicrobial activity of narasin against common clinical isolates associated with canine otitis externa. Veterinary Dermatology, 29, 149–157. https://doi.org/10.1111/vde.12516.

Chan, W. Y., Khazandi, M., Hickey, E. E., Page, S. W., Trott, D. J., & Hill, P. B. (2019). In vitro antimicrobial activity of seven adjuvants against common pathogens associated with canine otitis externa. Veterinary Dermatology, 30, 133–138. https://doi.org/10.1111/vde.12712.

Cole, L. K., Luu, D. H., Rajala-Schultz, P. J., Meadows, C., & Torres, A. H. (2007). In vitro activity of an ear rinse containing tromethamine, EDTA, benzyl alcohol and 0.1% ketoconazole on Malassezia organisms from dogs with otitis externa. Veterinary Dermatology, 18, 115–119. https://doi.org/10.1111/j.1365-3164.2007.00583.x.

Collignon, P. J., & McEwen, S. A. (2019). One health—its importance in helping to better control antimicrobial resistance. Tropical Medicine and Infectious Disease, 4(1), 22. https://doi.org/10.3390/tropicalmed4010022.

Corona, A., Vercelli, A., Bruni, N., Guidi, E., & Cornegliani, L. (2021). In vitro activity of lactoferricin solution against Malassezia pachydermatis from otitis externa in dogs and cats. Veterinary Dermatology, 32, 316–386. https://doi.org/10.1111/vde.12973.

Di Cerbo, A., Centenaro, S., Beribè, F., Laus, F., Cerquetella, M., Spaterna, A., Guidetti, A., Canello, S., & Terrazzano, G. (2016). Clinical evaluation of an anti-inflammatory and antioxidant diet effect in 30 dogs affected by chronic otitis externa: preliminary results. Veterinary Research Communications, 19, 280–287. https://doi.org/10.1111/j.1365-3164.2008.00688.x.

Dutra, T. V., Castro, J. C., Menezes, J. L., Ramos, T. R., Prado, I. N., Machinski, M., Mikcha, J. M. G., & Abreu Filho, B. A. (2019). Bioactivity of oregano (Origanum vulgare) essential oil against Alicyclobacillus spp. Industrial Crops and Products, 129. https://doi.org/10.1016/j.indcrop.2018.12.025

Ebani, V. V., Bertelloni, F., Najar, B., Nardoni, S., Pistelli, L., & Mancianti, F. (2020). Antimicrobial activity of essential oils against Staphylococcus and Malassezia strains isolated from canine dermatitis. Microorganisms, 8(2), 252. https://doi.org/10.3390/microorganisms8020252.

Gheller, B. G., Meirelles, A. C. F., Figueira, P. T., & Holsbach, V. (2017). Patógenos bacterianos encontrados em cães com otite externa e seus perfis de suscetibilidade a diversos antimicrobianos. PUBVET, 11(2), 159–167. https://doi.org/10.22256/pubvet.v11n2.159-167.

Glos, K., Linek, M., Loewenstein, C., Mayer, U., & Mueller, R. S. (2008). The efficacy of commercially available veterinary diets recommended for dogs with atopic dermatitis. Veterinary Dermatology, 19, 280–287. https://doi.org/10.1111/j.1365-3164.2008.00688.x.

Graham-Mize, C. A., & Rosser Junior, E. J. (2004). Comparison of microbial isolates and susceptibility patterns from the external ear canal of dogs with otitis externa. Journal American Animal Hospital Association, 40, 102–108. https://doi.org/10.5326/0400102.

Guillot, J., & Bond, R. (2020). Malassezia yeasts in veterinary dermatology: an updated overview. Frontiers in Cellular and Infection Microbiology, 10, 79. https://doi.org/10.3389/fcimb.2020.00079.

Henselm, P., Austel, M., Wooley, R. E., Keys, D., & Ritchie, B. W. (2009). In vitro and in vivo evaluation of a potentiated miconazole aural solution in chronic Malassezia otitis externa in dogs. Veterinary Dermatology, 20, 429–434. https://doi.org/10.1111/j.1365-3164.2009.00787.x.

Hurtado-Suárez, A., Pulido-Villamarín, A., Linares-Linares, M., Suárez-Fernández, L., Castañeda-Salazar, R., & Rodríguez-Bocanegra, M. (2016). Phenotypic characterization of canine Malassezia spp., isolates. Revista MVZ Cordoba, 21, 5535–5546.

Karlapudi, S. K. (2017). Diagnosis and management of Malassezia otitis in dogs. The Pharma Innovation Journal, 6, 36–38.

Kashif, M., Rizwan, M., Durrani, A. Z., Nasir, A., & Kim, G. (2016). Therapeutic trials to evaluate the efficacy of topical clotrimazole and nystatin on clinical cases of otitis externa in dogs caused by Malassezia pachydermatis in district Lahore and its suburbs in Pakistan. Journal of Biomedical and Translation Research, 17, 26–29. https://doi.org/10.12729/jbtr.2016.17.2.026.

Korbelik, J., Singh, A., Rousseau, J., & Weese, J. S. (2018). Analysis of the otic mycobiota in dogs with otitis externa compared to healthy individuals. Veterinary Dermatology, 29(417), e138. https://doi.org/10.1111/vde.12665.

Lee, T. H., Hyun, J. E., Kang, Y. H., Baek, S. J., & Hwang, C, Y. (2022). In vitro antifungal activity of cold atmospheric microwave plasma and synergistic activity against Malassezia pachydermatis when combined with chlorhexidine gluconate. Veterinary Medicine and Science, 8, 524–529. https://doi.org/10.1002/vms3.719.

Logas, D. B. (1994). Diseases of the ear canal. The Veterinary Clinics of North America. Small Animal Practice, 24, 905–919. https://doi.org/10.1016/s0195-5616(94)50108-6.

Maginn, K. (2016). Management of otitis externa and the veterinary nurse’s role. Veterinary Nurse, 7, 2–32. https://doi.org/10.12968/vetn.2016.7.1.25.

Marrero, E. J., Silva, F. A., Rosario, I., Déniz, S., Real, F., Padilha, D., Díaz, E. L., & Acosta-Hérnadez, B. (2017). Assessment of in vitro inhibitory activity of hydrogen peroxide on the growth of Malassezia pachydermatis and to compare its efficacy with commercial ear cleaners. Mycoses, 60, 645–650. https://doi.org/10.1111/myc.12637.

Martino, L., Nocera, F. P., Mallardo, K., Nizza, S., Masturzo, E., Fiorito, F., Iovane, G., & Catalanott, P. (2016). An update on microbiological causes of canine otitis externa in Campania Region, Italy. Asian Pacific Journal of Tropical Biomedicine, 6, 384–389. https://doi.org/10.1016/j.apjtb.2015.11.012.

Mason, C. L., Steen, S. I., Paterson, S., & Cripps, P. J. (2013). Study to assess in vitro antimicrobial activity of nine ear cleaners against 50 Malassezia pachydermatis isolates. Veterinary Dermatology, 24, 362–366. https://doi.org/10.1111/vde.12024.

Matos, A. M., Ornaghi, M. G., Carvalho, V. M., Avila, V. A. D., Bonin, E., Castilho, R. A., Ramos, A. V. G., Baldoqui, D. C., Prado, R. M., & Prado, I. N. (2021). Atividade antimicrobiana in vitro de uma combinação de óleos vegetais de caju e mamona e de óleos essenciais de cravo, eugenol, timol e vanilina contra bactérias Gram-negativas e Gram-positivas no rúmen de bovinos. Research, Society and Development, 10(8), 1–15. https://doi.org/10.33448/rsd-v1018.16900

McEwen, S. A., & Collignon, P. J. (2018). Antimicrobial resistance: a one health perspective. Microbiology Spectrum, 6(2), 2–6. https://doi.org/10.1093/trstmh/trx050.

Moulari, B., Pellequer, Y., Chaumont, J. P., Guillaume, Y. C., & Millet, J. (2007). In vitro antimicrobial activity of the leaf extract of Harungana madagascariensis Lam. Ex Poir. (Hypericaceae) against strains causing otitis externa in dogs and cats. Acta Veterinaria Hungarica, 55, 97–105. https://doi.org/10.1556/AVet.55.2007.1.10.

Nakano, Y., Matsuo, S., Tani, H., Sasai, K., & Baba, E. (2006). Therapeutic effects of beta-thujaplicin eardrops on canine Malassezia-related otitis externa. Journal Veterinary Medical Science. https://doi.org/10.1292/jvms.68.373.

Nakano, Y., Wada, M., Tani, H., Sasai, K., & Baba, E. (2005). Effects of beta-thujaplicin on anti-Malassezia pachydermatis remedy for canine otitis externa. The Journal Veterinary Medical Science, 67, 1243–1247. https://doi.org/10.1292/jvms.67.1243.

Nardoni, S., Pistelli, L., Baronti, I., Najar, B., Pisseri, F., Reidel, R. V. B., Papini, R., Perrucci, S., & Mancianti, F. (2017). Traditional mediterranean plants: characterization and use of an essential oils mixture to treat Malassezia otitis externa in atopic dogs. Natural Product Research, 31, 1891–1894. https://doi.org/10.1080/14786419.2016.1263853.

Noli, C., Sartori, R., & Cena, T. (2017). Impact of a terbinafine-florfenicol-betamethasone acetate otic gel on the quality of life of dogs with acute otitis externa and their owners. Veterinary Dermatology, 28, 386–390. https://doi.org/10.1111/vde.12433.

Nuttal, T. (2010). Enfermedades cutaneas del perro y el gato. Grupoasis, Zaragoza, Espanha.

Pinchbeck, L. R., Hillier, A., Kowalski, J. J., & Kwochka, K. W. (2002). Comparison of pulse administration versus once daily administration of itraconazole for the treatment of Malassezia pachydermatis dermatitis and otitis in dogs. Journal American Medical Association, 220, 1807–1812. https://doi.org/10.2460/javma.2002.220.1807.

Puig, L., Bragulat, M. R., Castellá, G., & Cabañes, F. J. (2017). Characterization of the species Malassezia pachydermatis and re-evaluation of its lipid dependence using a synthetic agar medium. PLoS One, 12(6), e0179148. https://doi.org/10.1371/journal.pone.0179148.

Puig, L., Castella, G., & Cabanes, F. J. (2019). Quantification of Malassezia pachydermatis by real-time PCR in swabs from the external ear canal of dogs. Journal of Veterinary Diagnostic Investigation, 31, 440–447. https://doi.org/10.1177/1040638719840686.

Puigdemont, A., D’Andreano, S., Ramio-Lluch, L., Cusco, A., Francino, O., & Brazis, P. (2021). Effect of an anti-inflammatory pomegranate otic treatment on the clinical evolution and microbiota profile of dogs with otitis externa. Veterinary Dermatology, 2, 137–158. https://doi.org/10.1111/vde.12930.

Rosychuk, R. A. W. (1994). Management of otitis externa. Veterinary Clinics of North America: Small Animal Practice, 24, 921–952. https://doi.org/10.1016/s0195-5616(94)50109-8.

Shaw, S. (2016). Pathogens in otitis externa: diagnostic techniques to identify secondary causes of ear disease. Practice, 38, 12–16. https://doi.org/10.1136/inp.i461.

Siemieniuk, M., Sosnowska, K., Czerniecki, J., Czyzewska, U., Winnicka, K., & Tylicki, A. (2018). Oxythiamine improves antifungal activity of ketoconazole evaluated in canine Malassezia pachydermatis strains. Veterinary Dermatology, 29, 476–480. https://doi.org/10.1111/vde.12688.

Sim, J. X. F., Khazandi, M., Chan, W. Y., Trott, D. J., & Deo, P. (2019). Antimicrobial activity of thyme oil, oregano oil, thymol and carvacrol against sensitive and resistant microbial isolates from dogs with otitis externa. Veterinary Dermatology, 30, 524–529. https://doi.org/10.1111/vde.12794.

Sim, J. X. F., Khazandi, M., Pi, H., Venter, H., Trott, D. J., & Deo, P. (2019). Antimicrobial effects of cinnamon essential oil and cinnamaldehyde combined with EDTA against canine otitis externa pathogens. Journal of Applied Microbiology, 127, 99–108. https://doi.org/10.1111/jam.14298.

Souza, H. B., Rodrigues, H. C., & Barreto, J. G. (2021). Isolamento microbiano e perfil de sensibilidade antimicrobiana de cães com otite externa atendidos na policlínica veterinária da Unig–campus v, Itaperuna, Rio de Janeiro. PUBVET, 16(4), 1–6. https://doi.org/10.31533/pubvet.v16n04a1087.1-6.

Swinney, A., Fazakerley, J., McEwan, N., & Nuttall, T. (2008). Comparative in vitro antimicrobial efficacy of commercial ear cleaners. Veterinary Dermatology, 19, 373–379. https://doi.org/10.1111/j.1365-3164.2008.00713.x.

Velegraki, A., Cafarchia, C., Gaitanis, G., Iatta, R., & Boekhout, T. (2015). Malassezia infections in humans and animals: pathophysiology, detection, and treatment. PLOS Pathogens, 11, e1004523. https://doi.org/10.1371/journal.ppat.1004523.

Vercelli, C., Pasquetti, M., Giovannetti, G., Visioni, S., Re, G., Giorgi, M., Gambino, G., & Peano, A. (2021). In vitro and in vivo evaluation of a new phytotherapic blend to treat acute externa otitis in dogs. Journal Veterinary of Pharmacology and Therapeutics, 44, 910–918. https://doi.org/10.1111/jvp.13000.

Yamamoto, D. M., Colino, V. C. M., Leal, C. R. B., & Babo-Terra, V. J. (2010). Otite externa canina em Campo Grande, Mato Grosso do Sul. PUBVET, 4, Art-893.

Downloads

Publicado

26-01-2024

Edição

Seção

Medicina veterinária

Como Citar

1.
Gomes RF, Mace MAM, Loreto Érico S de, Fuentefria AM, Zanette RA. Abordagens alternativas para tratamento da otite externa canina causada por Malassezia pachydermatis: Revisão e recomendações. Pubvet [Internet]. 26º de janeiro de 2024 [citado 27º de novembro de 2024];18(02):e1544. Disponível em: https://ojs.pubvet.com.br/index.php/revista/article/view/3465