Meningoencephalomyelitis caused by Cryptococcus spp. in a feline
DOI:
https://doi.org/10.31533/pubvet.v17n12e1497Keywords:
Cryptococcosis, yeast, neurological, central nervous systemAbstract
Cryptococcosis is a systemic mycosis caused by encapsulated yeasts from the gender Cryptococcus. It mainly affects the nasal cavity, adjacent tissue and lungs, and can spread to the central nervous system, eyes and skin, causing meningoencephalomyelitis. It can be noninfectious or infectious via yeasts and bacteria, and felines are the most prevalent when infected by the Feline Leukemia Virus (FeLV) or Feline Infectious Peritonits (FIP). The neurological signs of infection by criptococcus could be convulsion, depression, disorientation, ataxia, paralysis of the pelvic limbs, mydriasis and blindness. For diagnosis, the neurological exam is indispensable, and must be combined with the general full body physical exam, with the intention to find the injury. The aim of this study is to report the case of a cat, 10 months old, with meningoencephalomyelitis by Cryptococcus spp. The animal presented the clinical signs of abrupt change in behavior, excessive fear, lack of appetite and progressive weight loss. Methadone was administrated for the pain, used gabapentin that changed for pregabalin. Cerebrospinal fluid (CSF) analysis and MRI were performed to assist in the diagnosis. However, false negatives can occur, which may consequently hinder adequate treatment. In this report, diagnostic conclusion occurred post-mortem. Thus, the patient lacked the adequate treatment to stabilize in life.
References
Albright Junior, R. E., Christenson, R. H., Habig, R. L., Mears, T. P. & Schneider, K. A. (1988). Cerebrospinal fluid (CSF) TRAP: a method to improve CSF laboratory efficiency. American Journal of Clinical Pathology, 90(6), 707–710. https://doi.org/10.1093/ajcp/90.6.707.
Braund, K. G. (1994). Clinical syndromes in veterinary neurology. Mosby.
Braund, K. G. (2003). Clinical neurology in small animals-Localization, diagnosis and treatment. Citeseer.
Calesso, J. R., Oliveira, V. P., Jacob, M. G., Zacarias Júnior, A. & Hirata, K. Y. (2019). Diagnóstico citopatológico de criptococose em gata: Relato de caso. PUBVET, 13(10), 1–9. https://doi.org/10.31533/pubvet.v13n10a433.1-9.
Costa, F. V. A. & Norsworthy, G. D. (2013). Considerações especiais em felinos. In R. Rabelo (Ed.), Emergências de pequenos animais (p. 749). Elsevier Saunders.
Costa, R. C. & Dewey, C. W. (2016). Diferencial diagnosis. In Pratical guide tocanine and feline neurology (pp. 55–57). Elservier Sounders.
Cunningham, J. (2011). Tratado de fisiologia veterinária. Guanabara Koogan.
Damiani, J. D., Teixeira, A. F., Santos, D. P., Valente, L. G. S., Veronezi, L. O. & Souza, G. V. (2020). Criptococose felina: Relato de caso. PUBVET, 14(3), 1–5. https://doi.org/10.31533/pubvet.v14n3a524.1-5.
Dewey, C. W. (2008). Encephalopaties: Disorders of the brain. In C. W. Dewey (Ed.), A pratical guide to canine and feline neurology (pp. 115–220). Wiley Blackwell.
Dewey, C. W. (2016). Neurodiagnostic. In C. W. Dewey & R. C. Costa (Eds.), Pratical guide to canine and feline neurology. Elsevier Editora.
Faria, R. O. (2014). Fungos dimórficos e relacionados com micoses profundas. In M. M. Jericó, M. M. Kogika, & J. P. Andrade Neto (Eds.). Tratado de medicina interna de cães e gatos (p. 779). Koogan Guanabara.
Ferreira, A. J. A. (1989). Coleta, análise do líquido cefalorraquidiano e mielografia como meios complementares de diagnóstico. Revista Portuguesa de Ciências Veterinária, 14, 213–228.
Garosi, L. & Lowrie, M. (2013). The neurological examination. In BSAVA Manual of Canine and Feline Neurology (pp. 1–24). BSAVA Library. https://doi.org/10.1093/ONS/OPZ066.
Griffin, J. F., Levine, J. M., Levine, G. J. & Fosgate, G. T. (2008). Meningomyelitis in dogs: A retrospective review of 28 cases (1999 to 2007). Journal of Small Animal Practice, 49(10), 509–517. https://doi.org/10.1111/j.1748-5827.2008.00588.x.
Gunn-Moore, D. A. (2011). Cognitive dysfunction in cats: clinical assessment and management. Topics in Companion Animal Medicine, 26(1), 17–24.
Jericó, M. M., Andrade Neto, J. P. & Kogika, M. M. (2015). Tratado de medicina interna de cães e gatos. Roca Ltda.
Negrin, A., Lamb, C. R., Cappello, R. & Cherubini, G. B. (2007). Results of magnetic resonance imaging in 14 cats with meningoencephalitis. Journal of Feline Medicine and Surgery, 9(2), 109–116. https://doi.org/10.1016/j.jfms.2006.09.001.
Nessler, J., Wohlsein, P., Junginger, J., Hansmann, F., Erath, J., Söbbeler, F., Dziallas, P. & Tipold, A. (2020). Meningoencephalomyelitis of unknown origin in cats: a case series describing clinical and pathological findings. Frontiers in Veterinary Science, 7, 291. https://doi.org/10.3389/fvets.2020.00291.
Olby, N. (2010). The pathogenesis and treatment of acute spinal cord injuries in dogs. Veterinary Clinics: Small Animal Practice, 40(5), 791–807.
Penderis, J. (2013). Disorders of eyes and vision. In BSAVA Manual of Canine and Feline neurology (pp. 167–194). BSAVA Library. https://doi.org/10.22233/9781910443125.10.
Queiroz, J. P. A. F. (2008). Criptococose-Uma revisão bibliográfica. Acta Veterinaria Brasilica, 2(2), 32–38.
Sóila, R. (2014). Análise do líquido cefalorradiano. In M. M. Jericó, M. M. Kogika, & J. P. Andrade Neto (Eds.), Tratado de medicina interna de cães e gatos. Koogan Guanabara.
Summers, B. A., Cummings, J. F. & De Lahunta, A. (1995). Veterinary Neuropathology. Mosby-Year Book. Mosby Year Book.
Thomson. (2012). The neurologic examination and lesion localization. In Veterinary neuroanatomy a clinical approach (pp. 123–136). Saunders Elsevier.
Thomson, C. E., Kornegay, J. N. & Stevens, J. B. (1990). Analysis of cerebrospinal fluid from the cerebello medullary and lumbar cisterns of dogs with focal neurologic disease: 145 cases (1985-1987). Journal of the American Veterinary Medical Association, 196(11), 1841–1844.
Tipold, A. (2009). Treatment of primary central nervous system inflammation (encephalitis and meningitis). In J. D. Bonagura & D. C. Twedt (Eds.), Kirk’s current veterinary therapy (pp. 1070–1074). Sauders Elsevier.
Young, B. (2008). Encephalitis/Meningoencephalites. In W. Mai (Ed.), Diagnostic MRI in dogs and cats (p. 196). Taylor & Francis Group.
Zarfoss, M., Schatzberg, S., Venator, K., Cutter‐Schatzberg, K., Cuddon, P., Pintar, J., Weinkle, T., Scarlett, J. & Delahunta, A. (2006). Combined cytosine arabinoside and prednisone therapy for meningoencephalitis of unknown aetiology in 10 dogs. Journal of Small Animal Practice, 47(10), 588–595. https://doi.org/10.1111/j.1748-5827.2006.00172.x.
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