ACTH-dependent hypercortisolism in a female Shih-Tzu: Case report
DOI:
https://doi.org/10.31533/pubvet.v17n9e1454Keywords:
metabolic disorder, adrenal gland, hypercortisolism, Cushing's syndrome, trilostaneAbstract
Hyperadrenocorticism is a clinical condition of naturally or spontaneously occurring endogenous hypercortisolism, also known in veterinary medicine as Cushing's Syndrome. It is an endocrine disease commonly diagnosed in middle-aged to elderly dogs. It is characterized by high chronic concentrations of blood glucocorticoids that lead to laboratory alterations and clinical manifestations such as polyuria, polydipsia, polyphagia, dermatological alterations, pendular abdomen and muscle atrophy, among others. Etiologically, it is classified as spontaneous, related to adrenocorticotropic hormone (ACTH) -secreting pituitary adenomas, representing 80 to 85% cases, or cortisol-secreting adrenocortical tumors, corresponding to 15 to 20% cases of canine hyperadrenocorticism. We can also classify hypercortisolism as iatrogenic. Thus, the present study aimed to report the case of a 13-year-old female Shih-tzu, spayed, female patient who was diagnosed with hypercortisolism based on the correlation of clinical manifestations, physical examination findings, laboratory alterations and hormonal determinations (suppression test with low dose of dexamethasone and plasma ACTH) compatible with ACTH-dependent hypercortisolism. The pharmacological treatment instituted was Trilostane, demonstrating good clinical and laboratory control after 30 days of treatment.
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