Experimental poisoning of dogs with green leaves of Nerium oleander and use of fructose 1,6 diphosphate and glucose as treatments

Abstract

The N. oleander is a plant with worldwide distribution, especially in tropical and subtropical regions. These shrubs are often used as ornamental plants and have more than 30 cardiac glycosides cause the clinical picture of poisoning in canines. Knowing this, our study aimed to assess the changes clinical, electrocardiographic, biochemical and hematological kidney and also promote a possible therapeutic protocol evaluating the use of fructose 1,6 diphosphate and glucose in animals experimentally poisoned. Dogs showed clinical signs of poisoning such as vomiting, salivation, nausea, listlessness, ocular conjunctiva congested, dehydration, abdominal pain, tremors, diarrhea, loss of appetite and tenesmus. Was observed an increase of the biochemical GGTU, CK and CK-MB. By analyzing the electrocardiogram met arrhythmias as sinus bradycardia, second degree atrioventricular blocks, ventricular tachycardia and paroxysmal ventricular premature complex. Treatments, there was a significant improvement in the group treated with fructose 1,6 diphosphate. Concluded with this study that the animals intoxicated with 0.25 g / kg of green leaves of Nerium oleander in single dose, because clinical signs, laboratory findings and changes in the electrocardiogram tracing.