Diagnosis of discoid lupus erythematosus in a dog

Case report

Authors

DOI:

https://doi.org/10.31533/pubvet.v18n08e1645

Keywords:

Lupus, autoimmune disease, dermatology, histopathology

Abstract

In veterinary medicine one of the biggest challenges of the small clinic are the rare autoimmune diseases, especially on dermatology care, due to their complexity and lack of response to conventional skin treatments. Lupus erythematosus is one of these diseases that, in addition to affecting humans, is often diagnosed in dogs, and among its various classifications are systemic lupus erythematosus and discoid lupus erythematosus, which some authors believe to be a benign variation of the systemic lupus. The present study aims to report the case of a 9-year-old mixed-breed dog, rescued and kept in a veterinary clinic since its adoption as a puppy. In recent years, he has presented several dermatological manifestations, being seen by several clinicians with different empirical treatments without success in the therapeutic responses, then being referred to a dermatology specialist in search of a diagnosis. In this phase, the clinical signs were apathy, weight loss, facial (especially periocular) erythematous, ulcerated, and crusted lesions, moderate pruritus and loss of cobblestone architecture to the nasal planum. After screening for the underlying cause with cytological examination, there were signs for three differential diagnoses: lupus, ischemic dermatitis and dermatomyositis, requiring a biopsy for histopathological examination to define the cause. The diagnosis was then obtained as lymphoplasmacytic lichenoid dermatitis associated with edema and apoptosis of keratinocytes, a pattern compatible with discoid lupus erythematosus, demonstrating that the assertive choice of diagnostic methods was fundamental in implementing the correct treatment and obtaining the remission of the disease.

References

Banovic, F. (2019). Canine cutaneous lupus erythematosus: Newly discovered variants. Veterinary Clinics: Small Animal Practice, 49(1), 37–45. https://doi.org/10.1016/j.cvsm.2018.08.004.

Brkljačić, M., Kajin, F., Torti, M., Jović, I., Kiš, I., Šmit, I., Crnogaj, M., & Matijatko, V. (2017). Systemic lupus erythematosus: Diagnostic and treatment challenges. Veterinarski Glasnik, 71(2), 134–140.

Chabanne, L., Fournel, C., Rigal, D., & Monier, J.-C. (1999). Canine systemic lupus erythematosus. Part II. Diagnosis and treatment. Compendium on Continuing Education for the Practicing Veterinarian, 21(5), 402–411.

Gerhauser, I., Strothmann-Lüerssen, A., & Baumgärtner, W. (2006). A case of interface perianal dermatitis in a dog: is this an unusual manifestation of lupus erythematosus? Veterinary Pathology, 43(5), 761–764. https://doi.org/10.1354/vp.43-5-761.

Gross, T. L., Ihrke, P. J., Walder, J. E., & Affolter, K. V. (2009). Doenças de pele do cão e do gato: diagnóstico clínico e histopatológico. Editora Roca.

Guimarães, F. C., Conceição, R. T., Flaiban, K. K. M. C., & Arias, M. V. B. (2022). Estudo retrospectivo em 18 cães com lúpus eritematoso sistêmico (2008–2018). PUBVET, 16(2), 1–8. https://doi.org/10.31533/pubvet.v16n02a1032.1-8.

Horta, R. S., & Val, A. O. C. (2013). Exames complementares no diagnóstico dermatológico em pequenos animais. Cadernos Técnicos de Veterinária e Zootecnia, 71, 23–31.

Issa, M. C. A., & Manela-Azulay, M. (2010). Photodynamic therapy: a review of the literature and image documentation. Anais Brasileiros de Dermatologia, 85(4), 501–511.

Larsson, C. E., & Lucas, R. (2020). Tratado de medicina externa: Dermatologia veterinária. 2. ed., São Caetano do Sul – SP: Interbook, 145, 875-878.

Lima-Verde, J. F., Ferreira, T. C., & Nunes-Pinheiro, D. C. S. (2020). Lupus eritematoso discóide em cão: relato de caso. PUBVET, 14(1), 1–6. https://doi.org/10.31533/pubvet.v14n1a486.1-6

Loures, F. H., & Conceição, L. G. (2013). Biópsia de pele: Quando, onde e como. Maximizando benefícios. Cadernos Técnicos de Veterinária e Zootecnia, 71, 32.

Palumbo, M. I. P., Machado, L. H. A., Conti, J. P., Oliveira, F. C., & Rodrigues, J. C. (2010). Incidência das dermatopatias auto-imunes em cães e gatos e estudo retrospectivo de 40 casos de lupus eritematoso discóide atendidos no serviço de dermatologia da Faculdade de Medicina Veterinária e Zootecnia da UNESP – Botucatu. Semina: Ciências Agrárias, 31(3), 739–744. https://doi.org/10.5433/1679-0359.2010v31n3p739.

Patel, A., & Forsythe, P. J. (2011). Dermatologia em pequenos animais. Elsevier Brasil.

Pereira, P., Oyafuso, M. K. & Cunha, O. (2018). Coletânea de dermatologia veterinária. 1. ed., Curitiba – PR: Medvep, pp. 227-230.

Rhodes, K. H. Dermatopatias e otopatias: dermatoses imunomediadas. In: Birchard, S. J.; Sherding, R. G. Manual Saunders: Clínica de Pequenos Animais. 2. ed. São Paulo: Rocca, 2003.

Rhodes, K. H., & Werner, A. H. (2014). Dermatologia em Pequenos Animais, 2a edição (2 Ed.). Roca, São Paulo.

Silva, M. A. A., Soares, C. R. P., Melo, F. L., & Rocha, F. J. S. (2020). Leishmaniose Tegumentar Americana: Uma análise histopatológica e molecular em lesões de dermatites no estado de Pernambuco, Brasil. Revista Brasileira de Análises Clínicas, 51(4). https://doi.org/10.21877/2448-3877.201900774.

Silva, V. L., Monteiro, C. L. B., Silva, M. C., Carneiro, R. D., Pereira Júnior, E. R., & Lucena, L. V. (2018). Diagnóstico e tratamento de lúpus eritematoso discóide canino: Relato de caso. PUBVET, 12(3), 1–6. https://doi.org/10.22256/pubvet.v12n3a54.1-6.

Silvestrini, A. R., Costa, J. L., Silvestrini, G. R., Silvestrini, I. R., Gruenewald, A. P. C., & Reis, M. (2022). Lúpus eritematoso sistêmico: Relato de caso. PUBVET, 16(12), 1–6. https://doi.org/10.31533/pubvet.v16n12a1289.1-6.

Vettorato, E. D., & Novais-Mencalha, R. (2023). Lúpus eritematoso cutâneo crônico: Relato de caso. PUBVET, 17(6), e1396. https://doi.org/10.31533/pubvet.v17n6e1396.

Werner, A. H. (1999). Recognizing and treating discoid lupus erythematosus and pemphigus foliaceus in dogs. Veterinary Medicine, 94(11), 955–966.

Werner, B. (2009). Biópsia de pele e seu estudo histológico. Por quê? para quê? Como? Parte II. Anais Brasileiros de Dermatologia, 84(5). https://doi.org/10.1590/S0365-05962009000500010.

Published

2024-08-08

Issue

Section

Medicina veterinária

How to Cite

Diagnosis of discoid lupus erythematosus in a dog: Case report. (2024). Pubvet, 18(08), e1645. https://doi.org/10.31533/pubvet.v18n08e1645

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