Retrospective study of serum urea and creatinine in dogs with chronic renal failure treated with stem cells

Abstract

It was executed a retrospective study to compile and highlight information from the clinical history and laboratory exams of urea and creatinine in patients undergoing cell therapy for the treatment of chronic kidney disease. The sample consisted of 18 cases of dogs attended at the Clínica Veterinária Professor Israel, in the period between 01/01/2012 and 01/10/2016 with chronic renal disease and that were treated with stem cells. Most animals were older than 10 years, there was not a predisposition to one sex and 55% were diagnosed with other comorbidities. The study suggests that in general, cell therapy for the treatment of chronic kidney disease has a positive result. Animals with better results after treatment were those classified as IRIS I and IRIS II since the renal parenchyma was more preserved. Referring to animals classified as IRIS III, 55% also responded positively to the treatment, decreasing the serum levels of urea. However, animals classified as IRIS IV did not demonstrate the same results, as the parenchyma had been severely compromised and the disease had progressed.