Use of ganciclovir in the therapeutic approach to feline herpetic keratitis
Case report
DOI:
https://doi.org/10.31533/pubvet.v18n12e1701Keywords:
Antiviral, cats, FHV-1, ophthalmologyAbstract
Feline herpesvirus-1 (FHV-1) infection is widely prevalent in cats and can manifest through a variety of ocular clinical signs. Once infected, the feline will be a latent carrier for life, and recurrent clinical episodes of the virus may occur. The therapeutic approach depends on the stage of infection and the severity of the disease. The main elements of treatment are antiviral therapy, antibiotic therapy and supportive treatment. The antiviral ganciclovir in ophthalmic formulation is available for humans. However, there are anecdotal reports of its use in infected cats. Thus, our objective was to report a therapeutic approach with topical ganciclovir on the eye of a cat with FHV-1. The ophthalmic formulation of ganciclovir was shown to be well tolerated and effective in the ocular treatment of a cat with FHV-1.
References
Allerton, F., & Granick, J. (2023). Antimicrobial resistance: Should vets have prescriber autonomy or formulary restriction in small animal practice? Veterinary Record, 193(10). https://doi.org/10.1002/vetr.3702.
Andrew, S. E. (2001). Ocular manifestations of feline herpesvirus. Journal of Feline Medicine and Surgery, 3(1). https://doi.org/10.1053/jfms.2001.0110.
Bistner, S. I., Carlson, J. H., Shively, J. N., & Scott, F. W. (1971). Ocular manifestations of feline herpesvirus infection. Journal of the American Veterinary Medical Association, 159(10).
Chou, T. Y., & Hong, B. Y. (2014). Ganciclovir ophthalmic gel 0.15% for the treatment of acute herpetic keratitis: Background, effectiveness, tolerability, safety, and future applications. In Therapeutics and Clinical Risk Management (Vol. 10, Issue 1, pp. 665–681). https://doi.org/10.2147/TCRM.S58242.
Foote, A. R. (2021a). Corneal ulcers part 1: Aetiology and management of superficial corneal ulcers. The Veterinary Nurse, 12(5). https://doi.org/10.12968/vetn.2021.12.5.226.
Foote, A. R. (2021b). Corneal ulcers part 2: Aetiology and management of deep corneal ulcers. The Veterinary Nurse, 12(6). https://doi.org/10.12968/vetn.2021.12.6.286.
Gaskell, R. M., Dennis, P. E., Goddard, L. E., Cocker, F. M., & Wills, J. M. (1985). Isolation of felid herpesvirus I from the trigeminal ganglia of latently infected cats. Journal of General Virology, 66(2), 391–394. https://doi.org/10.1099/0022-1317-66-2-391.
Gelatt, K. N., Ben-Shlomo, G., Gilger, B. C., Hendrix, D. V. H., Kern, T. J., & Plummer, C. E. (2021). Veterinary ophthalmology. John Wiley & Sons.
Gould, D. (2011). Feline herpesvirus-1. Ocular manifestations, diagnosis and treatment options. In Journal of Feline Medicine and Surgery (Vol. 13, Issue 5, pp. 333–346). https://doi.org/10.1016/j.jfms.2011.03.010.
Groth, A. (2015). Slatter’s fundamentals of veterinary ophthalmology, 5th edition. Australian Veterinary Journal, 93(9). https://doi.org/10.1111/avj.12288.
Hartley, C. (2010). Aetiology of corneal ulcers. Assume FHV-1 unless proven otherwise. In Journal of Feline Medicine and Surgery (Vol. 12, Issue 1). https://doi.org/10.1016/j.jfms.2009.12.004.
Hillström, A., Tvedten, H., Källberg, M., Hanås, S., Lindhe, A., & Holst, B. S. (2012). Evaluation of cytologic findings in feline conjunctivitis. Veterinary Clinical Pathology, 41(2), 283–290. https://doi.org/10.1111/j.1939-165X.2012.00423.x.
Kartashov, S., Kartashova, E., Butenkov, A., Rakityanskaya, A., Petrova, M., Oboeva, M., & Sultanova, M. (2019). Corneal ulcers associated with FHV-1 in cats. IOP Conference Series: Earth and Environmental Science, 403(1), 012024. https://doi.org/10.1088/1755-1315/403/1/012024.
Ketring, K. L., & Glaze, M. B. (2012). Atlas of feline ophthalmology. In Atlas of Feline Ophthalmology. https://doi.org/10.1002/9781118704714.
Ledbetter, E. C., Badanes, Z. I., Chan, R. X., Donohue, L. K., Hayot, N. L., Harman, R. M., Van de Walle, G. R., & Mohammed, H. O. (2022). Comparative efficacy of topical ophthalmic ganciclovir and oral famciclovir in cats with experimental ocular feline herpesvirus-1 epithelial infection. Journal of Ocular Pharmacology and Therapeutics, 38(5). https://doi.org/10.1089/jop.2022.0001.
Lewin, A. C., Liu, C. C., Alling, C., Camacho-Luna, P., Miessler, B., & Carter, R. T. (2021). In vitro efficacy of ganciclovir against feline herpesvirus type 1 and assessment of ocular tolerability in healthy cats. Journal of Feline Medicine and Surgery, 23(4). https://doi.org/10.1177/1098612X20944363.
Lim, C., & Maggs, D. J. (2015). Oftalmologia. In S. E. Little (Ed.), O gato: medicina interna (pp. 1177–1178). Roca Ltda.
Maggs, D. J., & Clarke, H. E. (2004). In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. American Journal of Veterinary Research, 65(4). https://doi.org/10.2460/ajvr.2004.65.399.
Mironovich, M. A., Yoon, A., Marino, M. E., Ineck, N. E., Liu, C. C., Carter, R. T., & Lewin, A. C. (2023). Evaluation of compounded cidofovir, famciclovir, and ganciclovir for the treatment of feline herpesvirus ocular surface disease in shelter-housed cats. Veterinary Ophthalmology, 26(S1), 143–153. https://doi.org/10.1111/vop.13031.
Mitchcell, N., & Oliver, J. (2021). Feline Ophthalmology. The manual. Grupo Asís Biomedia SL.
Nasisse, M. P., Davis, B. J., Guy, J. S., Davidson, M. G., & Sussman, W. (1992). Isolation of feline Herpesvirus 1 from the Trigeminal ganglia of acutely and chronically infected Cats. Journal of Veterinary Internal Medicine, 6(2). https://doi.org/10.1111/j.1939-1676.1992.tb03159.x.
Oriá, A. P., Silveira, C. P. B., Souza, M. R., Pinna, M. H., Costa-Neto, J. M., & Dórea Neto, F. A. (2012). Síndromes oculares secundárias a infecção pelo Herpesvirus felino-1-Revisão. In Medicina Veterinaria (Brazil) (Vol. 6, Issue 4, pp. 16–25).
Rodriguez, J. M. M., Leeming, G., Köhler, K., & Kipar, A. (2017). Feline herpesvirus pneumonia: Investigations into the pathogenesis. Veterinary Pathology, 54(6). https://doi.org/10.1177/0300985817720982.
Stiles, J. (2014). Ocular manifestations of feline viral diseases. In Veterinary Journal (Vol. 201, Issue 2, pp. 166–173). https://doi.org/10.1016/j.tvjl.2013.11.018.
Thomasy, S. M., & Maggs, D. J. (2016). A review of antiviral drugs and other compounds with activity against feline herpesvirus type 1. In Veterinary Ophthalmology (Vol. 19). https://doi.org/10.1111/vop.12375.
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