Use of bedinvetmab for chronic pain control in a dog with osteoarthritis

Case report

Authors

  • Larissa Miziara Associação Nacional de Clínicos Veterinários de Pequenos Animais https://orcid.org/0009-0003-6033-9612
  • Fernanda Mergulhão Faculdade UPIS

DOI:

https://doi.org/10.31533/pubvet.v18n01e1528

Keywords:

Bedinvetmab, pain, osteoarthritis

Abstract

Osteoarthritis is currently the most commonly known joint condition in dogs. Its challenging classification and pain control have been the focus of studies and drug testing aimed at improving the quality of life for patients. This study aimed to evaluate the use of a canine monoclonal antibody for managing osteoarthritis pain, utilizing the pain guideline-approved scale as an evaluative method answered by the owner. Additionally, we sought to observe the response over one month of treatment. It presents a more practical therapeutic approach, well-received by owners, with fewer side effects compared to the use of anti-inflammatories.

References

Corral, M. J., Moyaert, H., Fernandes, T., Escalada, M., Tena, J. K. S., Walters, R. R., & Stegemann, M. R. (2021). A prospective, randomized, blinded, placebo-controlled multisite clinical study of bedinvetmab, a canine monoclonal antibody targeting nerve growth factor, in dogs with osteoarthritis. Veterinary Anaesthesia and Analgesia, 48(6), 943–955. https://doi.org/10.1016/j.vaa.2021.08.001.

Fernandes, M. L. (2013). Relação do exame físico e ultrassonográfico do segmento lombo-sacro-ilíaco e do disco invertebral da articulação lombossacral com desempenho atlético em equinos. Universidade de São Paulo.

Fritsch, D. A., Allen, T. A., Dodd, C. E., Jewell, D. E., Sixby, K. A., Leventhal, P. S., Brejda, J., & Hahn, K. A. (2010). A multicenter study of the effect of dietary supplementation with fish oil omega-3 fatty acids on carprofen dosage in dogs with osteoarthritis. Journal of the American Veterinary Medical Association, 236(5), 535–539. https://doi.org/10.2460/javma.236.5.535.

Johnson, K. A., Lee, A. H., & Swanson, K. S. (2020). Nutrition and nutraceuticals in the changing management of osteoarthritis for dogs and cats. Journal of the American Veterinary Medical Association, 256(12), 1335–1341. https://doi.org/10.2460/javma.256.12.1335.

Johnston, S. A. (1997). Osteoarthritis: joint anatomy, physiology, and pathobiology. Veterinary Clinics of North America: Small Animal Practice, 27(4), 699–723. https://doi.org/10.1016/s0195-5616(97)50076-3.

Kaminishi, Á. P. S., & Hirano, L. Q. L. (2017). Uso de gabapentina no controle da dor em pequenos animais: revisão de literatura. Revista Veterinária Em Foco, 14(2), 29–35.

Krautmann, M., Walters, R., Cole, P., Tena, J., Bergeron, L. M., Messamore, J., Mwangi, D., Rai, S., Dominowski, P., & Saad, K. (2021). Laboratory safety evaluation of bedinvetmab, a canine anti-nerve growth factor monoclonal antibody, in dogs. The Veterinary Journal, 276, 105733. https://doi.org/10.1016/j.tvjl.2021.105733.

Lamounier, A. R., Soares, J. O., Lage, M. H. H., & Melo, V. S. C. (2023). Osteoartrose de quadril em cães e gatos: Revisão. PUBVET, 17(2), 1–13. https://doi.org/10.31533/pubvet.v17n02a1347.

Lascelles, B. D. X., Knazovicky, D., Case, B., Freire, M., Innes, J. F., Drew, A. C., & Gearing, D. P. (2015). A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain. BMC Veterinary Research, 11(1), 1–12. https://doi.org/10.1186/s12917-015-0413-x.

Lomas, A. L., & Grauer, G. F. (2015). The renal effects of NSAIDs in dogs. Journal of the American Animal Hospital Association, 51(3), 197–203. https://doi.org/10.5326/JAAHA-MS-6239.

Mele, E. (2007). Epidemiologia da osteoartrite. Veterinary Focus, 17(3), 4–10.

Michels, G. M., Honsberger, N. A., Walters, R. R., Tena, J. K. S., & Cleaver, D. M. (2023). A prospective, randomized, double-blind, placebo-controlled multisite, parallel-group field study in dogs with osteoarthritis conducted in the United States of America evaluating bedinvetmab, a canine anti-nerve growth factor monoclonal antibody. Veterinary Anaesthesia and Analgesia, 50(5), 446–458. https://doi.org/10.1016/j.vaa.2023.06.003.

Mitoma, J., Kitaoka, M., Asakura, H., Anyenda, E. O., Hori, D., Tao, N. T. T., Hamagishi, T., Hayashi, K., Suzuki, F., & Shimizu, Y. (2016). Prevalence of chronic pain, especially headache, and relationship with health-related quality of life in middle-aged Japanese residents. Health, 8(1), 116–124. https://doi.org/10.4236/health.2016.81014.

Payne‐Johnson, M., Becskei, C., Chaudhry, Y., & Stegemann, M. R. (2015). Comparative efficacy and safety of mavacoxib and carprofen in the treatment of canine osteoarthritis. Veterinary Record, 176(11), 284. https://doi.org/10.1136/vr.102397.

Robertson-Plouch, C., Stille, J. R., Liu, P., Smith, C., Brown, D., Warner, M., Hu, L., & Fisher, M. J. (2019). A randomized clinical efficacy study targeting mPGES1 or EP4 in dogs with spontaneous osteoarthritis. Science Translational Medicine, 11(516), eaaw9993. https://doi.org/10.1126/scitranslmed.aaw9993.

Schmelz, M., Mantyh, P., Malfait, A.-M., Farrar, J., Yaksh, T., Tive, L., & Viktrup, L. (2019). Nerve growth factor antibody for the treatment of osteoarthritis pain and chronic low-back pain: mechanism of action in the context of efficacy and safety. Pain, 160(10), 2210. https://doi.org/10.1097/j.pain.000000000000162.

Sontag, S. C., Belletini, S. T., Tramontin, R. S., De Conti, J. B., Pachaly, E. M. V., Quessada, A. M., Rodrigues, N. S., & Pachaly, J. R. (2017). Utilização de gabapentina para manejo clínico de dor neuropática em cães: Relato de caso. Arquivos de Ciências Veterinárias e Zoologia da UNIPAR, 20(4). https://doi.org/10.25110/arqvet.v20i4.2017.6401.

Walton, M. B., Cowderoy, E., Lascelles, D., & Innes, J. F. (2013). Evaluation of construct and criterion validity for the ‘Liverpool Osteoarthritis in Dogs’(LOAD) clinical metrology instrument and comparison to two other instruments. PLoS One, 8(3), e58125. https://doi.org/10.1371/journal.pone.0058125.

Xie, J., Huang, Z., Yu, X., Zhou, L., & Pei, F. (2019). Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee. Cytokine & Growth Factor Reviews, 46, 36–44. https://doi.org/10.1016/j.cytogfr.2019.03.004.

Published

2023-12-14

Issue

Section

Medicina veterinária

How to Cite

Use of bedinvetmab for chronic pain control in a dog with osteoarthritis: Case report. (2023). Pubvet, 18(01), e1528. https://doi.org/10.31533/pubvet.v18n01e1528