Analgesic evaluation of methadone, in two doses associated with lidocaine without vasoconstrictor, epidurally in dogs submitted to elective orchiectomy

Abstract

Several drugs have used to control pain through various routes, such as epidural. Methadone is a synthetic morphine-like opioid and has used epidurally for pain control, especially during surgical procedures such as orchiectomy. Nine male dogs were selected for epidural methadone analgesic action study in two concentrations, 0.1mg/kg (M01) and 0.3 mg/kg (M03), associated with lidocaine without vasoconstrictor, the control group was appended. epidural lidocaine (LID). To evaluate the groups were measured and statistically analyzed the values of heart rate, respiratory rate, oxygen saturation, temperature and systolic blood pressure. The groups M01 and M03 did not differ statistically, the LID group presented different means of the groups M01 and M03 for the values of heart rate, oxygen saturation and diastolic blood pressure, confirming the need to use analgesic drugs in surgical procedures, especially at times of increased nociceptive stimulation.