Evaluation of the anti-inflammatory effect of dimethyl sulfoxide in bitches diagnosed with breast cancer and submitted to unilateral mastectomy

Abstract

The present study aimed to evaluate the anti-inflammatory effect of dimethyl sulfoxide (DMSO) in bitches diagnosed with breast cancer and submitted to unilateral mastectomy associated with ovariohysterectomy through lateral abdominal access. Twenty bitches of different breed and body mass diagnosed with breast cancer by cytopathological examination were used. All animals underwent a unilateral mastectomy and DMSO, at a dose of 1 g/kg, was administered intravenously, 15 min before the end of the surgical procedure (15PRE), 24 (24hPOST), and 48 h after the surgical procedure (48hPOST). The variables evaluated included respiratory rate, heart rate, body temperature, erythrogram, leukogram, serum blood biochemistry, macroscopic aspect of the wound surgical, and side effects of DMSO. The clinical parameters did not show significant differences between the evaluated moments. Body temperature showed a significant increase between 15PRE and 24hPOST; 24hPOST and 48hPOST. The values of erythrocytes, hemoglobin, platelets, total serum protein, and alanine aminotransferase showed significant variations throughout the evaluated time-points, however, the values remained within the physiological limit of the species. According to the results, it was concluded that dimethyl sulfoxide (DMSO) has an anti-inflammatory action in bitches submitted to unilateral mastectomy associated with ovariohysterectomy by lateral abdominal access, and safe when administered at a dose of 1 g / kg intravenously for three days.