Cutaneous calcinosis in a dog with hypercortisolism: Case report
DOI:
https://doi.org/10.31533/pubvet.v17n07a1423Keywords:
calcifications, dermatopathy, endocrinopathyAbstract
Cutaneous calcinosis in dogs is a dermatological condition that involves the deposition of calcium salts in the animals' skin. Its etiology has not yet been fully established, but it is believed that genetic, nutritional and metabolic factors may play an important role in the development of the disease. It is divided into four subtypes, according to its pathogenesis: dystrophic; metastatic; idiopathic and iatrogenic, with dystrophic being the most common. Hypercortisolism, also known as Cushing's syndrome, is one of the main causes of cutaneous calcinosis in dogs. In this condition, there is excessive production of cortisol by the adrenal glands, leading to a series of metabolic, immune and inflammatory changes that contribute to the formation of calcium deposits in the skin. Symptoms can vary, but they usually manifest as the formation of hard, white subcutaneous nodules that may ulcerate or leak creamy material. Diagnosis is performed through clinical and laboratory examinations, such as cytology of the nodules, biopsy, and laboratory tests. Treatment aims to control the underlying disease and provide local care, but it is quite challenging as there is no specific established therapy. This study aimed to report the case of a dog diagnosed with hypercortisolism, presenting secondary cutaneous calcinosis.
References
Boag, A. K. (2012). Ketoacidosis. In C. T. Mooney & M. E. Peterson (Eds.), Manual of canine and feline endocrionology (pp. 251–258). BSAVA. https://doi.org/10.22233/9781905319893.24
Coelho, H. E., Santos, R. L., & Alessi, A. C. (2016). Patologia veterinária. Roca Ltda.
Doerr, K. A., Outerbridge, C. A., White, S. D., Kass, P. H., Shiraki, R., Lam, A. T., & Affolter, V. K. (2013). Calcinosis cutis in dogs: Histopathological and clinical analysis of 46 cases. Veterinary Dermatology, 24(3), 355-E79. https://doi.org/10.1111/Vde.12026.
Ferguson, J. F. (1996). What is your diagnosis?[Calcinosis circumscripta in a dog]. In Generic.
Ferreira Filho, D. F., Fiuza, R. F., & Leite, A. K. R. (2013). Síndrome de cushing iatrogênica em cão: Relato de caso. Revista Cientifica Eletrônica de Medicina Veterinária, 21.
Jiang, S. W., Petty, A. J., & Nicholas, M. W. (2022). Innate immunity in calcinosis cutis. Immuno, 2(3), 443–459. https://doi.org/10.3390/immuno2030027.
Joffe, D. J. (1996). Calcinosis circumscripta in the footpad of a dog. The Canadian Veterinary Journal, 37(3), 161.
Kim, H. I., Kim, H. S., Yi, H. S., Kim, H. Y., & Kim, Y. S. (2021). A rare case of calcinosis cutis: easily mistaken as a foreign body. Journal of Wound Management and Research, 17(2), 150–153. https://doi.org/10.22467/jwmr.2020.01431.
Kooistra, H. S., & Galac, S. (2012). Recent advances in the diagnosis of Cushing’s syndrome in dogs. Topics in Companion Animal Medicine, 27(1), 21–24. https://doi.org/10.1053/j.tcam.2012.06.001.
Lee, E.-M., Kim, A.-Y., Lee, E.-J., & Jeong, K.-S. (2016). Pathomorphological features of calcinosis circumscripta in a dog. Laboratory Animal Research, 32, 74–77. https://doi.org/10.5625/lar.2016.32.1.74.
Łojszczyk-Szczepaniak, A., Orzelski, M., & Śmiech, A. (2008). Canine calcinosis circumscripta-retrospective studies. Medycyna Weterynaryjna, 64(12), 1397–1400.
McGavin, D., & Zachay, J. F. (2013). Bases da patologia em veterinária. Elsevier Brasil.
Oliveira, L. L. B., Konkel, C., Lewandowski, K. T., Barazetti, L., Orsi, M. L., Sousa, R. S., & Froes, T. R. (2023). Calcinose circunscrita no coxim plantar de um cão: Relato de caso. PUBVET, 17(6), e1399. https://doi.org/10.31533/pubvet.v17n6e1399.
Schofield, I., Brodbelt, D. C., Niessen, S. J. M., Church, D. B., Geddes, R. F., Kennedy, N., & O’Neill, D. G. (2020). Development and internal validation of a prediction tool to aid the diagnosis of Cushing’s syndrome in dogs attending primary‐care practice. Journal of Veterinary Internal Medicine, 34(6), 2306–2318. https://doi.org/10.1111/jvim.15851
Tafti, A. K., Hanna, P., & Bourque, A. C. (2005). Calcinosis circumscripta in the dog: a retrospective pathological study. Journal of Veterinary Medicine Series A, 52(1), 13–17. https://doi.org/10.1111/j.1439-0442.2004.00675.x.
Tolon, J. M. C., Jimenez, J. J. E., Irizar, I. G., & Trasobares, P. C. (2018). Resolution of iatrogenic calcinosis cutis in a dog through topical application of dmso. Veterinary Record Case Reports, 6(3), e000619. https://doi.org/10.1136/Vetreccr-2018-00061.
Zachary, J. F., McGavin, D., & McGavin, M. D. (2012). Bases da patologia em veterinária. Elsevier Brasil.
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