Aspects of the use of electrochemotherapy in dogs and cats: Review
DOI:
https://doi.org/10.31533/pubvet.v17n6e1398Keywords:
Electroporation, neoplasm, oncologyAbstract
Due to the increased longevity of dogs and cats, senile disorders have been more recurrent, such as neoplasms. In order to obtain better results in cancer therapy, electrochemotherapy (ECT) appears as a localized treatment of tumors, which associates chemotherapy drugs with electrical impulses. Thus, this study aims to discuss the therapeutic aspects of the use of ECT in companion animals, with emphasis on oral melanoma, cutaneous mastocytoma and squamous cell carcinoma. ECT is characterized by electroporation with high voltage intensity and ultra-short application time, with the associated use of chemotherapeutics such as bleomycin and cisplatin, to promote apoptosis and tissue necrosis. It is extremely important to stick to the particularities of each species, the route of administration, tumor size, dosage and side effects of drugs. Immunological and vascular secondary effects, due to damage to the endothelial tissue and vasoconstriction, are considered beneficial in tumor control. Different electrodes with different configurations and recommendations for use can be utilized, such as plate electrodes, or linear or hexagonal needle electrodes. The ECT technique promises fewer side effects and less invasive intervention when compared with surgical procedure and radiotherapy.
References
Abreu, R. S. (2019). Neoplasias em novos animais de companhia. Universidade de Lisboa, Lisboa, Portugal. https://doi.org/10.24873/j.rpemd.2019.09.455
Brunner, C. H. N. (2016). Eletroquimioterapia. In C. R. Daleck & A. B. De Nardi (Eds.), Oncologia em cães e gatos. Editora Roca.
Cadossi, R., Ronchetti, M., & Cadossi, M. (2014). Locally enhanced chemotherapy by electroporation: clinical experiences and perspective of use of electrochemotherapy. Future Oncology, 10(5), 877–890. https://doi.org/10.2217/fon.13.235.
Campana, L. G., Edhemovic, I., Soden, D., Perrone, A. M., Scarpa, M., Campanacci, L., Cemazar, M., Valpione, S., Miklavčič, D., & Mocellin, S. (2019). Electrochemotherapy–Emerging applications technical advances, new indications, combined approaches, and multi-institutional collaboration. European Journal of Surgical Oncology, 45(2), 92–102. https://doi.org/10.1016/j.ejso.2018.11.023.
Cemazar, M., Ambrozic Avgustin, J., Pavlin, D., Sersa, G., Poli, A., Krhac Levacic, A., Tesic, N., Lampreht Tratar, U., Rak, M., & Tozon, N. (2017). Efficacy and safety of electrochemotherapy combined with peritumoral IL‐12 gene electrotransfer of canine mast cell tumours. Veterinary and Comparative Oncology, 15(2), 641–654. https://doi.org/10.1111/vco.12208.
Cemazar, M., Sersa, G., Frey, W., Miklavcic, D., & Teissié, J. (2018). Recommendations and requirements for reporting on applications of electric pulse delivery for electroporation of biological samples. Bioelectrochemistry, 122, 69–76. https://doi.org/10.1016/j.bioelechem.2018.03.005.
Cemazar, M., Tamzali, Y., Sersa, G., Tozon, N., Mir, L. M., Miklavcic, D., Lowe, R., & Teissie, J. (2008). Electrochemotherapy in veterinary oncology. Journal of Veterinary Internal Medicine, 22(4), 826–831. https://doi.org/10.1007/978-3-319-32886-7_107.
Daleck, C. R., Fonseca, C. S., & Canola, J. C. (2016). Oncologia em cães e gatos. Roca.
Fernandes, S. C., & Nardi, A. D. B. N. (2016). Hemangiossarcomas. In C. R. Daleck, A. B. De Narde, & S. Rodaski (Eds.), Oncologia em cães e gatos (pp. 776–796). Roca, Brasil.
Florea, A.-M., & Büsselberg, D. (2011). Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects. Cancers, 3(1), 1351–1371. https://doi.org/10.3390/cancers3011351.
Giardino, R., Fini, M., Bonazzi, V., Cadossi, R., Nicolini, A., & Carpi, A. (2006). Electrochemotherapy a novel approach to the treatment of metastatic nodules on the skin and subcutaneous tissues. Biomedicine & Pharmacotherapy, 60(8), 458–462. https://doi.org/10.1016/j.biopha.2006.07.016.
Impellizeri, J., Aurisicchio, L., Forde, P., & Soden, D. M. (2016). Electroporation in veterinary oncology. The Veterinary Journal, 217, 18–25. https://doi.org/10.1016/j.tvjl.2016.05.015.
Kilari, D., Guancial, E., & Kim, E. S. (2016). Role of copper transporters in platinum resistance. World Journal of Clinical Oncology, 7(1), 106–113. https://doi.org/10.5306/wjco.v7.i1.106.
Kotnik, T., Rems, L., Tarek, M., & Miklavčič, D. (2019). Membrane electroporation and electropermeabilization: mechanisms and models. Annual Review of Biophysics, 48(6), 63–91. https://doi.org/10.1146/annurev-biophys-052118-115451.
Kulbacka, J., Paczuska, J., Rembiałkowska, N., Saczko, J., Kiełbowicz, Z., Kinda, W., Liszka, B., Kotulska, M., Kos, B., & Miklavčič, D. (2017). Electrochemotherapy combined with standard and CO2 laser surgeries in canine oral melanoma. Slovenian Veterinary Research, 54(4), 181–186. https://doi.org/10.26873/SVR-322-2017.
Lowe, R., Gavazza, A., Impellizeri, J. A., Soden, D. M., & Lubas, G. (2017). The treatment of canine mast cell tumours with electrochemotherapy with or without surgical excision. Veterinary and Comparative Oncology, 15(3), 775–784. https://doi.org/10.1111/vco.12217.
Mali, B., Miklavcic, D., Campana, L. G., Cemazar, M., Sersa, G., Snoj, M., & Jarm, T. (2013). Tumor size and effectiveness of electrochemotherapy. Radiology and Oncology, 47(1), 32–41. https://doi.org/10.2478/raon-2013-0002.
Miklavčič, D., Mali, B., Kos, B., Heller, R., & Serša, G. (2014). Electrochemotherapy: from the drawing board into medical practice. Biomedical Engineering Online, 13, 1–20. https://doi.org/10.1186/1475-925X-13-29.
Mir, L. M. (2006). Bases and rationale of the electrochemotherapy. European Journal of Cancer Supplements, 4(11), 38–44. https://doi.org/10.1016/j.ejcsup.2006.08.005.
Moreira, M. I., Rodrigues, M. C., Silva, F. L., Araújo, B. M., Gomes, M. S., Liarte, A. de S. C., & Nunes, M. H. V. (2017). Melanoma amelanótico oral em cão jovem: Relato de caso. Pubvet, 11(12), 1233–1238. https://doi.org/10.22256/pubvet.v11n12.1233-1238
Okino, M., & Mohri, H. (1987). Effects of a high-voltage electrical impulse and an anticancer drug on in vivo growing tumors. Japanese Journal of Cancer Research, 78(12), 1319–1321. https://doi.org/10.1007/BF02470769.
Oliveira Júnior, A. B., Largura, A. P. T., Cota, J. M., Lemos, V. Z., Strelow, I. M., Bedoya, A. O., Garcia-Castro, A. M., & Marcolongo-Pereira, C. (2022). Melanoma amelanótico cutâneo em um cão jovem. PUBVET, 16(6), 1–6. https://doi.org/10.31533/pubvet.v16n06a1127.1-6.
Otero, C. V. L., Duarte, E. G., Oliveira, P. P., Oliveira, T. E. de, & Lima, B. T. A. R. (2021). Eletroquimioterapia em mastocitoma canino: Relato de caso. PUBVET, 15(3), 1–8. https://doi.org/10.31533/pubvet.v15n03a774.1-8.
Spugnini, E., Azzarito, T., Fais, S., Fanciulli, M., & Baldi, A. (2016). Electrochemotherapy as first line cancer treatment: experiences from veterinary medicine in developing novel protocols. Current Cancer Drug Targets, 16(1), 43–52. https://doi.org/10.2174/156800961601151218155340.
Plaschke, C. C., Gothelf, A., Gehl, J., & Wessel, I. (2016). Electrochemotherapy of mucosal head and neck tumors: a systematic review. Acta Oncologica, 55(11), 1266–1272. https://doi.org/10.1080/0284186X.2016.1207803.
Rang, R., Ritter, J. M., Flower, R. J., & Henderson, G. (2015). Rang & dale farmacologia. Guanabara - Koogan.
Rangel, M. M. M., Fernandes, N. C. C., Nagamine, M. K., Fukumasu, H., Oliveira, K. D., Lowe, R., Mir, L. M., Sinhorini, I. L., & Dagli, M. L. Z. (2008). Eletroquimioterapia: uma nova promessa para o tratamento de cânceres em animais. Clínica Veterinária, 13(75), 30–36.
Santos, P. C. G., Costa, J. L., Miyazawa, C. R., & Shimizu, F. A. (2005). Melanoma canino. Revista Científica Eletretrônica de Medicina Veterinária, 6(5), 1–4.
Simčič, P., Lowe, R., Granziera, V., Pierini, A., Torrigiani, F., & Lubas, G. (2020). Electrochemotherapy in treatment of canine oral non‐tonsillar squamous cell carcinoma. A case series report. Veterinary and Comparative Oncology, 18(3), 428–432. https://doi.org/10.1111/vco.12530.
Simčič, P., Pierini, A., Lubas, G., Lowe, R., Granziera, V., Tornago, R., Valentini, F., Alterio, G., Cochi, M., & Rangel, M. M. M. (2021). A retrospective multicentric study of electrochemotherapy in the treatment of feline nasal planum squamous cell carcinoma. Veterinary Sciences, 8(3), 1–16. https://doi.org/10.3390/vetsci8030053.
Soltero-Rivera, M. M., & Reiter, A. M. (2020). Diseases of the oral cavity and salivary glands. In D. S. Bruyette (Ed.), Clinical small internal medicine. Editora Wiley-Blackwell. https://doi.org/10.1002/978119501237.
Spinosa, H. S. S., Górniak, S. L., & Bernardi, M. M. (2017). Farmacologia aplicada à medicina veterinária. Koogan Guanabara.
Suzuki, D. O. H., Berkenbrock, J. A., Frederico, M. J. S., Silva, F. R. M. B., & Rangel, M. M. M. (2018). Oral mucosa model for electrochemotherapy treatment of dog mouth cancer: ex vivo, in silico, and in vivo experiments. Artificial Organs, 42(3), 297–304. https://doi.org/10.1111/aor.13003.
Tellado, M., Michinski, S., Impellizeri, J., Marshall, G., Signori, E., & Maglietti, F. (2022). Electrochemotherapy using thin-needle electrode improves recovery in feline nasal planum squamous cell carcinoma-a translational model. Cancer Drug Resistance, 5(3), 595–611. https://doi.org/10.20517/cdr.2022.24.
Tellado, M. N., Maglietti, F. H., Michinski, S. D., Marshall, G. R., & Signori, E. (2020). Electrochemotherapy in treatment of canine oral malignant melanoma and factors influencing treatment outcome. Radiology and Oncology, 54(1), 68–78. https://doi.org/10.2478/raon-2020-0014.
Tilley, L. P., & Smith Junior, F. W. (2014). Consulta veterinária em 5 minutos. Manole Ltda.
Tozon, N., Tratar, U. L., Znidar, K., Sersa, G., Teissie, J., & Cemazar, M. (2016). Operating procedures of the electrochemotherapy for treatment of tumor in dogs and cats. Journal of Visualized Experiments, 116(e54760), 1–7. https://doi.org/10.3791/54760.
Vail, D. M. (2007). Feline lymphoma and lymphoid leukemis. In S. J. Withrow & E. G. MacEwen (Eds.), Small animal clinical oncology (pp. 733–752). Sauders Elsevier.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Luciano de Paulo Moreira, Poliana Laviola Pedrosa, Bruno Passagem Ventura, Jhulya de Andrade Borges Vieira, Maria Mauri Marques, Isabelly Santos Vale, Tathiany Tavares Costa, Ruslana Simonassi da Silva, Igor Cezar Kniphoff da Cruz, Paulo Sérgio Cruz de Andrade, Karina Preising Aptekmann
This work is licensed under a Creative Commons Attribution 4.0 International License.
Você tem o direito de:
Compartilhar — copiar e redistribuir o material em qualquer suporte ou formato
Adaptar — remixar, transformar, e criar a partir do material para qualquer fim, mesmo que comercial.
O licenciante não pode revogar estes direitos desde que você respeite os termos da licença. De acordo com os termos seguintes:
Atribuição
— Você deve dar o crédito apropriado, prover um link para a licença e indicar se mudanças foram feitas. Você deve fazê-lo em qualquer circunstância razoável, mas de nenhuma maneira que sugira que o licenciante apoia você ou o seu uso. Sem restrições adicionais
— Você não pode aplicar termos jurídicos ou medidas de caráter tecnológico que restrinjam legalmente outros de fazerem algo que a licença permita.
