Diagnosis of pituitary pars intermedia dysfunction in equine: case report

Authors

  • Luzia Leon Coelho Leal Universidade Federal do Rio Grande do Sur
  • Kennya Mansiero Sanson Couto Souto Maior Universidade Federal do Rio Grande do Sur
  • Flávia Umpierre Bueno Universidade Federal do Rio Grande do Sur
  • Carlos Afonso de Castro Beck

DOI:

https://doi.org/10.31533/pubvet.v16n01a1007.1-5

Keywords:

Hirsutism, dexamethasone, neurodegenerative disease, pituitary pars intermedia disfunction

Abstract

Pituitary Pars Intermedia Dysfunction (PPID), also called equine Cushing's disease, is the most common endocrine disorder of elderly horses. A variable combination of clinical signs is observed, the most common being hirsutism. The diagnosis is based on the clinical signs presented and laboratory tests of the baseline ACTH concentration or the dexamethasone suppression test, the most commonly used ones. In this study, the diagnosis of PPID in a mare, Creole, 24 years old, is reported by means of the dexamethasone suppression test and hirsutism as the only clinical sign.

References

Arnaldi, G., Angeli, A., Atkinson, A. B., Bertagna, X., Cavagnini, F., Chrousos, G. P., Fava, G. A., Findling, J. W., Gaillard, R. C., & Grossman, A. B. (2003). Diagnosis and complications of Cushing’s syndrome: a consensus statement. The Journal of Clinical Endocrinology & Metabolism, 88(12), 5593–5602. https://doi.org/10.1210/jc.2003-030871.

Del Pino, F. J. G. (2009). Síndrome de Cushing en Equinos (Equine Cushing’s. REDVET, 10(7).

Del Pino, T. S., Pazinato, F. M., & Curcio, B. R. (2017). Síndrome de Cushing em égua da raça crioula - relato de caso.

Durham, A. E., McGowan, C. M., Fey, K., Tamzali, Y., & Van der Kolk, J. H. (2014). Pituitary pars intermedia dysfunction: diagnosis and treatment. Equine Veterinary Education, 26(4), 216–223.

Dybdal, N. O., Hargreaves, K. M., Madigan, J. E., Gribble, D. H., Kennedy, P. C., & Stabenfeldt, G. H. (1994). Diagnostic testing for pituitary pars intermedia dysfunction in horses. Journal of the American Veterinary Medical Association, 204(4), 627–632.

Elliott, M. (2001). Cushing’s Disease: a new approach to therapy in equine and canine patients. British Homoeopathic Journal, 90(1), 33–36.

Franco, F. A., Santos, F. C. C., Costa, G. V., Oliveira, H. R., Ugolini, L. W., Bondan, C., & Alves, L. P. (2021). Conduta diagnóstica em equino da raça Crioula com síndrome de Cushing. Acta Scientiae Veterinariae, 49(1), 598.

Hatazoe, T., Kawaguchi, H., Hobo, S., & Misumi, K. (2015). Pituitary pars intermedia dysfunction (equine Cushing’s disease) in a Thoroughbred stallion: a single report. Journal of Equine Science, 26(4), 125–128.

Kastelan, D., Dusek, T., Kraljevic, I., Polasek, O., Giljevic, Z., Solak, M., Salek, S. Z., Jelcic, J., Aganovic, I., & Korsic, M. (2009). Hypercoagulability in Cushing’s syndrome: the role of specific haemostatic and fibrinolytic markers. Endocrine, 36(1), 70–74. https://doi.org/10.1007/s12020-009-9186-y.

Kooistra, H. S., & Galac, S. (2012). Recent advances in the diagnosis of Cushing’s syndrome in dogs. Topics in Companion Animal Medicine, 27(1), 21–24. https://doi.org/10.1053/j.tcam.2012.06.001.

McGowan, C. (2013). Hyperadrenocorticism (Pituitary Pars Intermedia Dysfunction) in horses. Clinical Endocrinology of Companion Animals, 11, 100–114.

McGowan, T. W., Pinchbeck, G. P., & McGowan, C. M. (2012). Prevalence, risk factors and clinical signs predictive for equine pituitary pars intermedia dysfunction in aged horses. Equine Veterinary Journal, 45(1), 74–79.

Monteiro, R. M. S. F. L. (2015). Abordagem à disfunção da PARS Intermedia da glândula pituitária de equinos. Universidade Federal do Rio Grande do Sul.

Pereira, M. A. A., Araújo, R. S., & Bisi, H. (2001). Síndrome de Cushing associada à hiperplasia macronodular das adrenais: apresentação de um caso e revisão da literatura. Arquivos Brasileiros de Endocrinologia & Metabologia, 45(6), 619–627.

Schott, H. C. (2002). Pituitary pars intermedia dysfunction: equine Cushing’s disease. Veterinary Clinics: Equine Practice, 18(2), 237–270.

Smets, P., Meyer, E., Maddens, B., & Daminet, S. (2010). Cushing’s syndrome, glucocorticoids and the kidney. General and Comparative Endocrinology, 169(1), 1–10. https://doi.org/10.1016/j.ygcen.2010.07.004.

Published

2022-01-28

Issue

Section

Medicina veterinária

How to Cite

Diagnosis of pituitary pars intermedia dysfunction in equine: case report. (2022). Pubvet, 16(01), e1007. https://doi.org/10.31533/pubvet.v16n01a1007.1-5