Survey on the therapeutic use of Canabidiol by veterinarians in the metropolitan region of Belém do Pará

Authors

DOI:

https://doi.org/10.31533/pubvet.v18n04e1582

Keywords:

cannabidiol, Cannabis sativa, veterinarian doctors

Abstract

The present study aimed to analyze the knowledge of veterinarians in the metropolitan region of Belém do Pará regarding the use of Cannabis sativa for medicinal purposes in veterinary medicine. To this end, structured questionnaires were applied through the google forms platform. The data obtained were presented in percentages in order to collect information on this subject, which is of fundamental importance for the creation of dissemination strategies regarding the medicinal use of Cannabis. More than 40% of respondents claim to have gained knowledge on the matter through scientific articles and understand the importance of its integration into the clinical routine, and more than 90% believe that research on the use of medicinal Cannabis needs to be stimulated and have greater dissemination. The affirmation of the need for more studies on the use of cannabidiol in small animals is clear in the common opinion of the interviewees, including the need to utilize tools such as social media to bring this knowledge to people who can be both professionals in the area, as well as tutors who are interested in the subject.

References

Bow, E. W., & Rimoldi, J. M. (2016). The structure-function relationships of classical cannabinoids: CB1/CB2 modulation. Perspectives in Medicinal Chemistry, 8. https://doi.org/10.4137/PMC.S32171.

Brutlag, A., & Hommerding, H. (2018). Toxicology of marijuana, synthetic cannabinoids, and cannabidiol in dogs and cats. Veterinary Clinics: Small Animal Practice, 48(6), 1087–1102. https://doi.org/10.1016/j.cvsm.2018.07.008.

Carlini, E. A. (2006). A história da maconha no Brasil. In Jornal Brasileiro de Psiquiatria (Vol. 55, Issue 4). https://doi.org/10.1590/S0047-20852006000400008.

Carvalho, M. S., Mota, A. A. R., Silva, J. B. M. A., & Nascimento, G. P. V. (2023). O uso terapêutico do canabidiol (CDB) no tratamento de transtornos de ansiedade de depressão. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 4(1). https://doi.org/10.47820/recima21.v4i1.4049.

Castro Neto, A. G., Escobar, J. A. C., & Lira, W. L. (2020). A história da primeira tentativa de produção de medicamentos à base de maconha: Entrevista com Antônio José Alves. Ciência & Saúde Coletiva, 25(6). https://doi.org/10.1590/1413-81232020256.24612018.

CFMV. (2017). Código de ética do médico veterinário. Diário Oficial da União.

Correia-da-Silva, G., Fonseca, B. M., Soares, A., & Teixeira, N. (2019). Canabis e canabinoides para fins medicinais. Revista Portuguesa de Farmacoterapia, 11(1), 21–31.

Cristino, L., Bisogno, T., & Marzo, V. (2020). Cannabinoids and the expanded endocannabinoid system in neurological disorders. Nature Reviews Neurology, 16(1), 9–29. https://doi.org/10.1038/s41582-019-0284-z.

Briyne, N., Holmes, D., Sandler, I., Stiles, E., Szymanski, D., Moody, S., Neumann, S., & Anadón, A. (2021). Cannabis, cannabidiol oils and tetrahydrocannabinol - What do veterinarians need to know? In Animals (Vol. 11, Issue 3). https://doi.org/10.3390/ani11030892.

Della Rocca, G., & Di Salvo, A. (2020). Hemp in Veterinary Medicine: From Feed to Drug. In Frontiers in Veterinary Science (Vol. 7). https://doi.org/10.3389/fvets.2020.00387.

Dinis-Oliveira, R. J. (2019). A perspectiva da toxicologia clínica sobre a utilização terapêutica da cannabis e dos canabinoides. Acta Médica Portuguesa, 32(2), 87–90. https://doi.org/10.20344/amp.10896.

Diniz, E. N. de C., Freato, A. H. C., Neres, B. C. R., Pimentel, V. C., Carvalho, R. A., Novais, T. M. G., Melo, C. D., Pachêco, W. B., Barros, P. T. S., Silva, M. R. C., & Oliveira, P. L. L. (2023). O benefício do uso terapêutico do canabidiol no tratamento da esclerose múltipla. In Pesquisa em saúde e meio ambiente: uma perspectiva em saúde coletiva - Volume 3. https://doi.org/10.29327/5308778.1-9.

Fitzgerald, K. T., Bronstein, A. C., & Newquist, K. L. (2013). Topical review marijuana poisoning. Elsevier, 28(1), 8–12.

Gamble, L.-J., Boesch, J. M., Frye, C. W., Schwark, W. S., Mann, S., Wolfe, L., Brown, H., Berthelsen, E. S., & Wakshlag, J. J. (2018). Pharmacokinetics, safety, and clinical efficacy of cannabidiol treatment in osteoarthritic dogs. Frontiers in Veterinary Science, 23, 165. https://doi.org/10.3389/fvets.2018.00165.

Gontiès, B. (2003). Maconha: uma perspectiva histórica, farmacológica e antropológica. Mneme - Revista de Humanidades, 4(7).

Guerrero-Alba, R., Barragán-Iglesias, P., González-Hernández, A., Valdez-Moráles, E. E., Granados-Soto, V., Condés-Lara, M., Rodríguez, M. G., & Marichal-Cancino, B. A. (2019). Some prospective alternatives for treating pain: the endocannabinoid system and its putative receptors GPR18 and GPR55. Frontiers in Pharmacology, 9, 1496. https://doi.org/10.3389/fphar.2018.01496.

Gyles, C. (2016). Marijuana for pets? The Canadian Veterinary Journal, 57(12), 1215.

Hanuš, L. O., Meyer, S. M., Muñoz, E., Taglialatela-Scafati, O., & Appendino, G. (2016). Phytocannabinoids: A unified critical inventory. In Natural Product Reports (Vol. 33, Issue 12). https://doi.org/10.1039/c6np00074f.

Kogan, L., Schoenfeld-Tacher, R., Hellyer, P., & Rishniw, M. (2019). US veterinarians’ knowledge, experience, and perception regarding the use of cannabidiol for canine medical conditions. Frontiers in Veterinary Science, 5(JAN). https://doi.org/10.3389/fvets.2018.00338.

Ligresti, A., Petrocellis, L., & Marzo, V. (2016). From phytocannabinoids to cannabinoid receptors and endocannabinoids: Pleiotropic physiological and pathological roles through complex pharmacology. Physiological Reviews, 96(4), 1593–1659. https://doi.org/10.1152/physrev.00002.2016.

Lu, H. C., & MacKie, K. (2016). An introduction to the endogenous cannabinoid system. In Biological Psychiatry (Vol. 79, Issue 7). https://doi.org/10.1016/j.biopsych.2015.07.028.

Machado, T. D., Santos, L. C. M., Alves, M. A. S., Cacciacarro, B. S., & Mendonça, F. S. (2022). Óleo de canabidiol para controle de dor em cão: Relato de caso. PUBVET, 16(11), 1–4. https://doi.org/10.31533/pubvet.v16n11a1261.1-4.

McGrath, S., Bartner, L. R., Rao, S., Packer, R. A., & Gustafson, D. L. (2019a). Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy. Journal of the American Veterinary Medical Association, 254(11). https://doi.org/10.2460/javma.254.11.1301.

McGrath, S., Bartner, L., Rao, S., Packer, R., & Gustafson, D. (2019b). the Effect of Oral Cannabidiol Administration in Addition. Journey of the American Veterinary Medical Association, 254(11).

Morales, P., & Jagerovic, N. (2020). Novel approaches and current challenges with targeting the endocannabinoid system. In Expert Opinion on Drug Discovery (Vol. 15, Issue 8). https://doi.org/10.1080/17460441.2020.1752178.

Oliveira, H. A. (2022). Estudo das propriedades físico-químicas e terapêuticas do óleo de canabidiol extraído da planta Cannabis sativa. Instituto Federal Goiano.

Pellati, F., Borgonetti, V., Brighenti, V., Biagi, M., Benvenuti, S., & Corsi, L. (2018). Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer. In BioMed Research International (Vol. 2018). https://doi.org/10.1155/2018/1691428.

Pereira, H. C. S. (2020). Análise do conhecimento de brasileiros acerca da Cannabis sativa l. (maconha) e seu uso terapêutico na Medicina Veterinária. Universidade Federal da Paraíba.

Pesce, M., Esposito, G., & Sarnelli, G. (2018). Endocannabinoids in the treatment of gastrointestinal inflammation and symptoms. Current Opinion in Pharmacology, 43, 81–86. https://doi.org/10.1016/j.coph.2018.08.009.

Pope, C., Mechoulam, R., & Parsons, L. (2010). Endocannabinoid signaling in neurotoxicity and neuroprotection. NeuroToxicology, 31(5). https://doi.org/10.1016/j.neuro.2009.12.002.

Rodrigues, B. B., Alvarenga, L. C. R., & Aguiar, C. (2022). Uso terapêutico do canabidiol nos transtornos de ansiedade e insônia. Brazilian Journal of Development, 8(12). https://doi.org/10.34117/bjdv8n12-152.

Silva, A. K., Janovik, N., & Oliveira, R. R. (2020). Canabidiol e seus efeitos terapêuticos. In A. Diehl & C. Pillon (Eds.), Maconha: prevenção, tratamento e políticas públicas (pp. 110–112). Artmed Editora.

Silva, M. V. V., Jesus, L. S. De, Prates, Y. C., Santos, J. A. dos, & Silveira, M. S. (2022). Uso terapêutico do canabidiol em doenças neurodegenerativas. https://doi.org/10.54265/aafx5241.

Silver, R. J. (2019). The endocannabinoid system of animals. Animals, 9, 2–15. https://doi.org/10.7551/mitpress/10457.003.0003.

Sousa, L. T. N., Daibert, A. P., & Dias, A. P. N. (2023). Canabidiol para o controle da dor em pequenos animais: Revisão. PUBVET, 17(11), e1477. https://doi.org/10.31533/pubvet.v17n11e1477.

Viana, F. A. B. (2014). Guia terapêutico veterinário. Editora Guanabara Koogan.

Viana, L. S., Silva, T. A., Antunes, V. M. S., & Gonzaga, R. V. (2021). Efeito do óleo de canabidiol (CBD) sobre a acne. Research, Society and Development, 10(14), e306101422075–e306101422075. https://doi.org/10.33448/rsd-v10i14.22075.

Vieira, L. S., Marques, A. E. F., & Sousa, V. A. (2020). O uso de Cannabis sativa para fins terapêuticos no Brasil: Uma revisão de literatura. Scientia Naturalis, 2(2), 1–10.

Wang, J., & Ueda, N. (2009). Biology of endocannabinoid synthesis system. Prostaglandins & Other Lipid Mediators, 89(3–4), 112–119. https://doi.org/10.1016/j.prostaglandins.2008.12.002.

Published

2024-04-08

Issue

Section

Medicina veterinária

How to Cite

Survey on the therapeutic use of Canabidiol by veterinarians in the metropolitan region of Belém do Pará. (2024). Pubvet, 18(04), e1582. https://doi.org/10.31533/pubvet.v18n04e1582